DL-Mevalonolactone , 98% , 674-26-0

Synonym(s):
(±)-β-Hydroxy-β-methyl-δ-valerolactone;(±)-3-Hydroxy-3-methyl δ-valerolactone;DL-Mevalolactone;DL-Mevalonic acid lactone

CAS NO.：674-26-0

Empirical Formula: C6H10O3

Molecular Weight: 130.14

MDL number: MFCD00006648

EINECS: 211-615-0

PRODUCT Properties

• Melting point: 28 °C(lit.)
• Boiling point: 145-150 °C5 mm Hg(lit.)
• alpha: -1.0～+1.0°(20℃/D)(c=5, C2H5OH)
• Density: 1.1066 (rough estimate)
• refractive index: n20/D 1.473(lit.)
• Flash point: >230 °F
• storage temp.: -20°C
• solubility: Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate, Methanol (Slightly)
• form: Oil
• pka: 13.57±0.20(Predicted)
• color: Pale Yellow to Dark Brown
• Merck: 14,6163
• BRN: 80960
• Stability: Hygroscopic
• InChIKey: JYVXNLLUYHCIIH-UHFFFAOYSA-N
• CAS DataBase Reference: 674-26-0(CAS DataBase Reference)
• NIST Chemistry Reference: Dl-mevalonic acid lactone(674-26-0)

Description and Uses

DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.

(±)-Mevalonolactone is used to:

• study the effect of statin on the prenylation of Ras and Rho GTPases
• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)

Safety

• WGK Germany: 3
• F: 3-10
• HS Code: 29322090