Biochanin A , 98% , 491-80-5
Synonym(s):
4′-Methylgenistein;5,7-Dihydroxy-4′-methoxyisoflavone;Genistein 4′-methyl ether;Olmelin
CAS NO.：491-80-5
Empirical Formula: C16H12O5
Molecular Weight: 284.26
MDL number: MFCD00006839
EINECS: 207-744-7
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB195.20 | In Stock |
|
| 1G | RMB458.40 | In Stock |
|
| 5G | RMB1410.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 210-213 °C(lit.) |
| Boiling point: | 340-355 °C(Press: 0.5 Torr) |
| Density | 1.420±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | acetone: 10 mg/mL, clear, brown |
| pka | 6.50±0.20(Predicted) |
| form | Powder |
| color | Off-White to Beige |
| Water Solubility | Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C). |
| λmax | 263nm(EtOH)(lit.) |
| BRN | 278107 |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | HUMECTANT SKIN PROTECTING SKIN CONDITIONING |
| InChI | InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3 |
| InChIKey | WUADCCWRTIWANL-UHFFFAOYSA-N |
| SMILES | C1OC2=CC(O)=CC(O)=C2C(=O)C=1C1=CC=C(OC)C=C1 |
| LogP | 3.341 (est) |
| CAS DataBase Reference | 491-80-5(CAS DataBase Reference) |
| EPA Substance Registry System | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5) |
Description and Uses
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein , another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM).
An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene
