Home Categories Biochemical Engineering 1,8-Dihydroxy-3-methylanthraquinone
A3105412

1,8-Dihydroxy-3-methylanthraquinone , Analysis of standard products, ≥98% , 481-74-3

Synonym(s):
1,8-Dihydroxy-3-methylanthraquinone;3-Methylchrysazin;Chrysophanic acid

CAS NO.:481-74-3

Empirical Formula: C15H10O4

Molecular Weight: 254.24

MDL number: MFCD00001208

EINECS: 207-572-2

Pack Size Price Stock Quantity
20MG RMB81.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 194-198 °C
Boiling point: 357.45°C (rough estimate)
Density  1.2693 (rough estimate)
refractive index  1.4872 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  chloroform: soluble1%
form  crystalline
pka 6.63±0.20(Predicted)
color  yellow-orange
Water Solubility  <0.1 g/100 mL at 18 ºC
λmax 429nm(MeOH)(lit.)
Merck  14,2258
BRN  1252300
Stability: Stable. Incompatible with strong oxidizing agents.
LogP 4.720 (est)

Description and Uses

Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).

A topical ointment used in the treatment of dermal conditions such as eczema and herpes.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/38-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  CB6725000
8-10
HS Code  29146990

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