Home Categories Chemical Reagents Dimethyl fumarate
A3164512

Dimethyl fumarate , 99% , 624-49-7

Synonym(s):
Dimethyl fumarate;Fumaric acid dimethyl ester

CAS NO.:624-49-7

Empirical Formula: C6H8O4

Molecular Weight: 144.13

MDL number: MFCD00064438

EINECS: 210-849-0

Pack Size Price Stock Quantity
25G RMB47.20 In Stock
100G RMB67.20 In Stock
250g RMB79.20 In Stock
500G RMB120.00 In Stock
2.5kg RMB559.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 102-106 °C (lit.)
Boiling point: 192-193 °C (lit.)
Density  1,37 g/cm3
vapor pressure  5 hPa (25 °C)
refractive index  1.4062 (estimate)
Flash point: 192-193°C
storage temp.  Store below +30°C.
solubility  1.6g/l
form  Liquid
color  Clear colorless to faintly yellow
PH 4.0-6.0 (10g/l, H2O, 20℃)suspension
Water Solubility  Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck  14,4287
BRN  774590
Stability: Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.

Description and Uses

In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.

Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing

Safety

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H312-H315-H317-H335-H411
Precautionary statements  P261-P264-P271-P273-P280-P302+P352+P312
Hazard Codes  Xn
Risk Statements  21-38-41-43-36/37/38-36/38
Safety Statements  26-36/37/39-36/37
RIDADR  UN 3077 9 / PGIII
WGK Germany  1
RTECS  EM6125000
TSCA  Yes
HS Code  29171990
Toxicity LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg

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