2'-Deoxy-2'-fluorouridine , 98% , 784-71-4

CAS NO.：784-71-4

Empirical Formula: C9H11FN2O5

Molecular Weight: 246.19

MDL number: MFCD01317293

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 147.0 to 153.0 °C
• Density: 1.63±0.1 g/cm3(Predicted)
• refractive index: 53 ° (C=0.3, H2O)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Soluble in methanol.
• form: Powder
• pka: 9.39±0.10(Predicted)
• color: White to Off-white
• optical activity: α20/D +53°±3°, c = 0.3 in water
• Water Solubility: soluble in water
• InChI: InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
• InChIKey: UIYWFOZZIZEEKJ-XVFCMESISA-N
• SMILES: OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
• CAS DataBase Reference: 784-71-4(CAS DataBase Reference)

Description and Uses

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H315-H319-H335-H341b
• Precautionary statements: P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c
• Hazard Codes: Xn
• Risk Statements: 20/21/22-40
• Safety Statements: 22-36/37/39
• HS Code: 29389090