Fexofenadine HCl , ≥98% , 153439-40-8
Synonym(s):
Fexofenidine hydrochloride;MDL 16455 hydrochloride;Terfenidine carboxylate hydrochloride
CAS NO.：153439-40-8
Empirical Formula: C32H40ClNO4
Molecular Weight: 538.13
MDL number: MFCD08064193
EINECS: 604-906-2
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB79.20 | In Stock |
|
| 1g | RMB239.20 | In Stock |
|
| 5g | RMB640.00 | In Stock |
|
| 25g | RMB1440.00 | In Stock |
|
| 100g | RMB5119.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 148-150oC |
| RTECS | CY1633377 |
| storage temp. | 2-8°C |
| solubility | Soluble in Dimethyl sulfoxide (50 mM), and methanol. |
| form | powder |
| color | white to beige |
| Merck | 14,4068 |
| InChIKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| CAS DataBase Reference | 153439-40-8(CAS DataBase Reference) |
Description and Uses
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).
Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H317-H360-H312 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P302+P352-P312-P322-P363-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2933399090 |
