Insulin from porcine pancreas , ≥27USPunits/mg , 12584-58-6

Synonym(s):
Insulin from hog pancreas;Insulin from porcine pancreas

CAS NO.：12584-58-6

Empirical Formula: C256H381N65O76S6

Molecular Weight: 5777.54

MDL number: MFCD00164155

EINECS: 235-703-3

PRODUCT Properties

• storage temp.: -20°C
• solubility: It can be solubilized in dilute acetic or hydrochloric acid, pH 2-3.
• form: powder
• color: White to Off-White
• biological source: Porcine pancreas
• Merck: 13,5003
• Specific Activity: ≥27USP units/mg
• Sequence: Chain 1:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala Chain 2:Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn (Disulfide bridge:1'Cys7-2'Cys7,1'Cys19-2'Cys20,1'Cys6-2'Cys11)
• Stability: Hygroscopic

Description and Uses

Porcine Insulin is a double-chain protein with a molecular mass of 5778, containing 51 amino acids (A-21 and B-30 chains) connected by a disulfide bond. Porcine Insulin has a high degree of similarity to human insulin, differing only in the 30th amino acid. porcine Insulin regulates the uptake, utilisation and storage of glucose, amino acids and fatty acids in cells and inhibits the breakdown of glycogen, proteins and lipids. Therefore, it is used to control hyperglycaemia in diabetic patients.

Porcine Insulin, from porcine pancreas, is used in the determination of the beta-cell reserve during glucose tolerance test or after a carbohydrate rich meal, as a guide for the instauration of insulin therapy, contribution to the diagnosis of insulin and non-insulin-dependent diabetes, characterisation and follow-up of states of glucose intolerance, diagnosis and study of cases of insulin resistance, diagnosis of insulinoma and other causes of hypoglycemia.

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: NM8895000
• F: 10
• HS Code: 2937120000