Ki16425 , ≥98% , 355025-24-0

CAS NO.：355025-24-0

Empirical Formula: C23H23ClN2O5S

Molecular Weight: 474.96

MDL number: MFCD06798341

PRODUCT Properties

• Melting point: 59.5-60.5 °C
• Boiling point: 623.7±55.0 °C(Predicted)
• Density: 1.353
• storage temp.: -20°C
• solubility: DMSO: 16 mg/mL
• form: solid
• pka: 4.32±0.10(Predicted)
• color: white

Description and Uses

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA_1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA₁ and LPA₃. It exhibits K_i values of 0.34, 6.5, and 0.93 μM for the human LPA₁, LPA₂, and LPA₃ receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.

Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HS Code: 29349990