Linderane , Analysis of standard products, ≥98% , 13476-25-0
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB504.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 190～191℃ |
| Boiling point: | 434.5±45.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Description and Uses
Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.
Linderane is a sequiterpene lactone extract from Lindera strychnifolia compound used as a cytotoxic agent against hepaic stellate cells.
Safety
| Safety Statements | 24/25 |
| HS Code | 29322090 |
