Lomustine , 98% , 13010-47-4

Synonym(s):
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea;Lomustine

CAS NO.：13010-47-4

Empirical Formula: C9H16ClN3O2

Molecular Weight: 233.7

MDL number: MFCD00012392

EINECS: 235-859-2

PRODUCT Properties

• Melting point: 88-90
• Boiling point: 63.6°C (rough estimate)
• Density: 1.3840 (rough estimate)
• refractive index: 1.5790 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
• form: Solid
• pka: 10.88±0.20(Predicted)
• color: Light orange to Yellow to Green
• Merck: 14,5564
• InChI: InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
• InChIKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N
• SMILES: N(CCCl)(N=O)C(NC1CCCCC1)=O
• CAS DataBase Reference: 13010-47-4(CAS DataBase Reference)
• IARC: 2A (Vol. 26, Sup 7) 1987
• EPA Substance Registry System: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (13010-47-4)

Description and Uses

Lomustine is a pale yellow powder. Molecularweight = 233.73; Freezing/Melting point = 90℃. Insolublein water.

Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H350
• Precautionary statements: P201-P280-P301+P330+P331+P310-P308+P313
• Hazard Codes: T
• Risk Statements: 45-25
• Safety Statements: 53-45
• RIDADR: 3249
• WGK Germany: 3
• RTECS: YS4900000
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29299090
• Hazardous Substances Data: 13010-47-4(Hazardous Substances Data)
• Toxicity: LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)