Lansoprazole , ≥98% , 103577-45-3

Synonym(s):
2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl]-1H-benzimidazole;LAN;Lansoprazole

CAS NO.：103577-45-3

Empirical Formula: C16H14F3N3O2S

Molecular Weight: 369.36

MDL number: MFCD00866873

EINECS: 2017-001-1

PRODUCT Properties

• Melting point: 178-182°C dec.
• Boiling point: 555.8±60.0 °C(Predicted)
• Density: 1.50±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, soluble in anhydrous ethanol, very slightly soluble in acetonitrile.
• pka: pKa 2.34±0.37 (Occasionally);3.53±0.37 (Occasionally);8.48±0.30 (Occasionally)
• form: powder
• color: off-white
• Merck: 14,5362
• BCS Class: 2
• InChI: InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
• InChIKey: MJIHNNLFOKEZEW-UHFFFAOYSA-N
• SMILES: C1(S(CC2=NC=CC(OCC(F)(F)F)=C2C)=O)NC2=CC=CC=C2N=1
• CAS DataBase Reference: 103577-45-3(CAS DataBase Reference)

Description and Uses

Lansoprazole is a proton pump inhibitor that inhibits the H⁺/K⁺-ATPase. It inhibits K⁺ and H⁺ accumulation in gastric microsomes in a concentration-dependent manner (IC₅₀s = 6.3 and 7.0 μM, respectively) and inhibits H⁺/K⁺-ATPase activity by approximately 60% when used at a concentration of 10 μM. Lansoprazole inhibits the H⁺/K⁺-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion. Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: DD9487500
• HS Code: 29339900
• Hazardous Substances Data: 103577-45-3(Hazardous Substances Data)
• Toxicity: dog,LD,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993.