A6207412
BKM120 , ≥99% , 944396-07-0
CAS NO.：944396-07-0
Empirical Formula: C18H21F3N6O2
Molecular Weight: 410.39
MDL number: MFCD18251596
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB511.20 | In Stock |
|
| 10MG | RMB910.40 | In Stock |
|
| 50MG | RMB1759.20 | In Stock |
|
| 250mg | RMB6687.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 143-147°C |
| Boiling point: | 645.7±65.0 °C(Predicted) |
| Density | 1.382 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (15 mg/ml) |
| form | White powder. |
| pka | 5.94±0.50(Predicted) |
| color | White |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110? = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
A selective Class I PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50s of 50-300 nM.
Safety
| Symbol(GHS) |   GHS08,GHS06 |
| Signal word | Danger |
| Hazard statements | H372-H341-H301 |
| Precautionary statements | P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| HS Code | 29349990 |
