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A6813112

Phenytoin , ≥99% , 57-41-0

Synonym(s):
5,5-Diphenyl-2,4-imidazolidinedione;5,5-Diphenylhydantoin;Phenytoin

CAS NO.:57-41-0

Empirical Formula: C15H12N2O2

Molecular Weight: 252.27

MDL number: MFCD00005264

EINECS: 200-328-6

Pack Size Price Stock Quantity
25G RMB44.00 In Stock
100G RMB126.40 In Stock
250G RMB216.80 In Stock
500G RMB424.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 293-295 °C (lit.)
Boiling point: 395.45°C (rough estimate)
Density  1.1562 (rough estimate)
refractive index  1.5906 (estimate)
Flash point: 11 °C
storage temp.  2-8°C
solubility  DMSO: soluble
form  Powder
pka pKa 8.43(H2O,t =25,I=0.025) (Uncertain)
color  White to almost white
Water Solubility  <0.01 g/100 mL at 19 ºC
Merck  14,7322
BRN  384532
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey CXOFVDLJLONNDW-UHFFFAOYSA-N

Description and Uses

The drug was first approved for the treatment of epilepsy by the Food and Drug Administration in 1953 and marketed by Parke-Davis as Dilantin. Its primary mechanism of action appears to block voltage-sensitive sodium channels in the brain (especially in the motor cortex), producing a delay in electrical recovery in neurons and stabilizing the threshold against hyperexcitability.

Phenytoin has the same main effects on the heart as lidocaine. Its use is essentially limited, and it is primarily used only as an oral replacement of lidocaine for paroxysmal tachycardia that is caused particularly by intoxication of digitalis drugs.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H351-H360FD
Precautionary statements  P201-P202-P264-P270-P301+P312-P308+P313
Hazard Codes  T,Xn,F
Risk Statements  45-61-22-63-40-39/23/24/25-23/24/25-11-20/21/22
Safety Statements  53-45-36/37-16-7
RIDADR  2811
WGK Germany  3
RTECS  MU1050000
Autoignition Temperature 550 °C
HazardClass  6.1(b)
PackingGroup  II
HS Code  29332100
Toxicity LD50 in mice (mg/kg): 92 i.v.; 110 s.c. (Stille, Brunckow)

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