Promethazine hydrochlorine , >98.0%(HPLC) , 58-33-3

Synonym(s):
10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride;Promethazine hydrochloride

CAS NO.：58-33-3

Empirical Formula: C17H21ClN2S

Molecular Weight: 320.88

MDL number: MFCD00012652

EINECS: 200-375-2

PRODUCT Properties

• Melting point: 230-232°C
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Very soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
• color: White to Almost white
• PH: pH (50g/L, 25℃) : 4.0～6.0
• λmax: 297nm(H2O)(lit.)
• Merck: 14,7786
• BRN: 4166397
• BCS Class: 1,3
• InChI: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
• InChIKey: XXPDBLUZJRXNNZ-UHFFFAOYSA-N
• SMILES: N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl

Description and Uses

Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.

Safety

• Symbol(GHS): GHS05,GHS07,GHS09
• Signal word: Danger
• Hazard statements: H302-H317-H318-H411
• Precautionary statements: P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn,N
• Risk Statements: 22-36/37/38-51/53-43-20/22
• Safety Statements: 26-36-61-60-36/37/39-28-22
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: SO8225000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29343000
• Toxicity: LD50 i.v. in mice: 55.0 mg/kg (Rajsner)