4μ8C , 10mMinDMSO , 14003-96-4
Synonym(s):
7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde;8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III;IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 189-190℃ (ethanol ) |
| Boiling point: | 398.3±42.0 °C(Predicted) |
| Density | 1.541 |
| refractive index | 1.641 |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 6.22±0.20(Predicted) |
| form | Yellow powder |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | RTHHSXOVIJWFQP-UHFFFAOYSA-N |
| CAS DataBase Reference | 14003-96-4 |
Description and Uses
4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50?= 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity.1?Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells.2?Blocks production of IL-4, IL-5 and IL-13 production in T cells.3?4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.4
8-Formyl-4-methylumbelliferone is an inhibitor that blocks substrate access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H315-H317-H319-H334-H335-H350 |
| Precautionary statements | P201-P202-P261-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P308+P313-P342+P311-P362+P364-P403+P233-P501c |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
