ML297 , 10mMinDMSO , 1443246-62-5
Synonym(s):
1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea;1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, N-(3,4-Difluorophenyl)-Nʹ-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, CID 56642816, VU0456810;CID 56642816;GIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem;VU0456810
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB262.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 377.8±42.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 12.54±0.70(Predicted) |
| form | White powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Description and Uses
ML297 (1443246-62-5) is a selective GIRK 1/2 (Kir3.1/3.2) channel activator, IC50?= 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2??Displays antiseizure activity2?and decreases anxiety-related behavior without sedative or addictive effects3. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells.4?Brain penetrant.
ML 297 is an anxiolytic drug which acts as a selective Kir3.1/3.2 (GIRK1/2) channel activator. It may be used in the treatment of epileptic seizures.
