GSK4716 , 10mMinDMSO , 101574-65-6
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB170.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.12 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: >10mg/mL |
| form | powder |
| pka | 8.48±0.15(Predicted) |
| color | white to off-white |
Description and Uses
The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
Selective agonist at estrogen-related receptors ERR and ERR
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H410 |
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50/53 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| HazardClass | 9 |
