Fluralaner , 10mMinDMSO , 864731-61-3

CAS NO.：864731-61-3

Empirical Formula: C22H17Cl2F6N3O3

Molecular Weight: 556.29

MDL number: MFCD30533410

EINECS: 689-035-6

PRODUCT Properties

• Density: 1.51±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMSO:150.0(Max Conc. mg/mL);269.65(Max Conc. mM); Ethanol:25.0(Max Conc. mg/mL);44.94(Max Conc. mM)
• pka: 12.50±0.46(Predicted)
• form: A crystalline solid
• color: White to off-white
• InChIKey: MLBZKOGAMRTSKP-UHFFFAOYSA-N
• SMILES: C(NCC(=O)NCC(F)(F)F)(=O)C1=CC=C(C2CC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)ON=2)C=C1C

Description and Uses

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

Fluralaner(864731-61-3) is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H360-H410
• Precautionary statements: P201-P202-P273-P281-P308+P313-P391-P405-P501