Fumagillin , 10mMinDMSO , 23110-15-8

Synonym(s):
Fugillin

CAS NO.：23110-15-8

Empirical Formula: C26H34O7

Molecular Weight: 458.54

MDL number: MFCD03990453

EINECS: 245-433-8

PRODUCT Properties

• Melting point: 194-195℃
• alpha: D25 -26.6° (c = 1 in 95% ethanol)
• Boiling point: 484.03°C (rough estimate)
• Density: 1.1368 (rough estimate)
• refractive index: 1.5800 (estimate)
• Flash point: 2℃
• storage temp.: 2-8°C
• solubility: ethanol: 1 mg/mL
• form: powder
• pka: 4.27±0.10(Predicted)
• color: white
• Sensitive: Air Sensitive
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: NGGMYCMLYOUNGM-ZILXAVPASA-N
• LogP: 3.260 (est)

Description and Uses

Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2; IC₅₀ = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells when used at a concentration of 5 μg/ml. In vivo, fumagillin (30 mg/kg per day) decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. It also reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity. Formulations containing fumagillin have been used to treat conjunctival and intestinal microsporidial infections in immunocompromised patients.

Methionine aminopeptidase 2 inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn,F
• Risk Statements: 22-36-20/21/22-11
• Safety Statements: 36-36/37-16-24/25
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: HE1750000
• HS Code: 29419090
• Toxicity: LD50 in mice (mg/kg): ~800 s.c. (DiPaolo)