Tideglusib , ≥98% , 865854-05-3

Synonym(s):
4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;NP031112;NP-12

CAS NO.：865854-05-3

Empirical Formula: C19H14N2O2S

Molecular Weight: 334.39

MDL number: MFCD18633296

EINECS: 640-411-8

PRODUCT Properties

• Melting point: 148 - 150oC
• Boiling point: 511.3±43.0 °C(Predicted)
• Density: 1.393
• storage temp.: 2-8°C
• solubility: DMSO: >15mg/mL
• form: powder
• pka: -1.51±0.20(Predicted)
• color: white to beige
• InChI: InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
• InChIKey: PMJIHLSCWIDGMD-UHFFFAOYSA-N
• SMILES: S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C1=C2C(C=CC=C2)=CC=C1

Description and Uses

Tideglusib has been used:

• as a reference compound in ADP-GloTM Kinase assay
• as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis
• as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
• WGK Germany: 3