Vinblastine sulfate , ≥97%(HPLC) , 143-67-9

Synonym(s):
Vinblastine Sulfate - CAS 143-67-9 - Calbiochem;Vinblastine sulfate salt;Vincaleukoblastine sulfate salt;VLB

CAS NO.：143-67-9

Empirical Formula: C46H60N4O13S

Molecular Weight: 909.05

MDL number: MFCD00082457

EINECS: 205-606-0

PRODUCT Properties

• Melting point: 267 °C (dec.)(lit.)
• alpha: -21.7 º (c=2, CH3OH 21 ºC)
• storage temp.: 2-8°C
• solubility: H₂O: 10 mg/mL
• form: powder
• color: white
• PH: 3.5～5.0 (1g/l, 25℃)
• Water Solubility: >=1 g/100 mL at 24.5 ºC
• Merck: 13,10044
• BRN: 3659812
• InChIKey: KDQAABAKXDWYSZ-PNYVAJAMSA-N
• CAS DataBase Reference: 143-67-9(CAS DataBase Reference)
• IARC: 3 (Vol. 26, Sup 7) 1987
• EPA Substance Registry System: Vinblastine sulfate (143-67-9)

Description and Uses

Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase. Chemical and physical evidence indicate that vinblastine sulfate is a dimeric alkaloid containing both indole and dihydroindole moieties.

Vinblastin sulfate USP (Velban) is used to treat Hodgkin’s disease; lymphosarcoma; reticulum cell sarcoma; neuroblastoma; choriocarcinoma; carcinoma of breast, lung, oral cavity, testis, bladder; acute and chronic leukemia; histiocytosis; mycosis fungoides.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H341-H361fd
• Precautionary statements: P202-P264-P270-P280-P301+P312-P308+P313
• Hazard Codes: Xn,T
• Risk Statements: 22-37/38-41-61-36/37/38-63-23/24/25
• Safety Statements: 26-36/39-53-45-37/39-36/37/39
• RIDADR: 1544
• WGK Germany: 3
• RTECS: YY8400000
• F: 8-10
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29399990
• Toxicity: LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich)