Xanthohumol , ≥97.0%(HPLC) , 6754-58-1
Synonym(s):
(E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)propenone;2′,4,4′-Trihydroxy-6′-methoxy-3′-prenylchalcone;2′,4,4′-Trihydroxy-6′-methoxy-3′-prenylchalcone
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB47.20 | In Stock |
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| 25MG | RMB79.20 | In Stock |
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| 10MG | RMB176.80 | In Stock |
|
| 100mg | RMB242.40 | In Stock |
|
| 250mg | RMB371.20 | In Stock |
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| 1g | RMB928.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 157-159℃ |
| Boiling point: | 576.5±50.0 °C(Predicted) |
| Density | 1.244 |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble10mg/mL |
| form | powder |
| pka | 7.59±0.45(Predicted) |
| color | Yellow |
| biological source | plant (Humulus lupulus) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+ |
| InChIKey | ORXQGKIUCDPEAJ-YRNVUSSQSA-N |
| SMILES | C(C1=C(OC)C=C(O)C(C/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1 |
| LogP | 5.172 (est) |
Description and Uses
Xanthohumol(XH, 6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II) Impairs prostate cancer cell growth and proliferation Cell permeable.
Xanthohumol from hop (Humulus lupulus) has been used:
to treat glioblastoma cells to test its effect on inducing apoptosis
to test its protective effect in renal ischemia/reperfusion (I/R) injury
as a component of Dulbecco′s modified Eagle medium (DMEM) to test its antiviral activity in Huh7.5 cells infected with hepatitis C virus cell culture (HCVcc) system
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H400 |
| Precautionary statements | P273-P280 |
| Hazard Codes | N,Xi |
| Risk Statements | 50/53-43 |
| Safety Statements | 60-61-45-22 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | UD5574117 |
| HS Code | 29145090 |
