![(S)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoicacid](https://img.chemicalbook.com/CAS/GIF/51543-39-6.gif)
(S)-2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoicacid , 98+% , 51543-39-6
CAS NO.：51543-39-6
Empirical Formula: C15H13FO2
Molecular Weight: 244.26
MDL number: MFCD00866152
EINECS: 257-263-1
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB1260.80 | In Stock |
|
| 250mg | RMB2103.20 | In Stock |
|
| 1g | RMB6637.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 109-110 °C(lit.) |
| Boiling point: | 376.2±30.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | insoluble in H2O; ≥10.9 mg/mL in DMSO; ≥69.1 mg/mL in EtOH |
| form | A crystalline solid |
| pka | 4.14±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/s3 |
| InChIKey | SYTBZMRGLBWNTM-JQHDBZEONA-N |
| SMILES | C1(=CC=C([C@H](C)C(=O)O)C=C1F)C1=CC=CC=C1 |&1:4,r| |
Description and Uses
Marketed by Taisho Pharmaceutical Holdings Co., Ltd., and Teijin Pharma Ltd., the (S)-enantiomer of flurbiprofen (named Esflurbiprofen) was approved as a new drug by the PMDA of Japan in 2015. (S)- Flurbiprofen, a cyclooxygenase (COX)-inhibiting nonsteroidal anti-inflammatory (NSAID) drug, is formulated with mentha oil and administered by way of a patch as a treatment for osteoarthritis in the current invention. Interestingly, the (R)- enantiomer is responsible for minimal COX inhibition but has been implicated as a possible treatment for a variety of other diseases. Synthetic approaches to racemic flurbiprofen have been reported in the chemical literature as early as the 1960s, and the mixture was approved as a drug in the United States by the FDA in 1988, marketed by Pharmacia and Upjohn. Toward this end, the current patent estate defines the utility of the active S-enantiomer, and synthetic approaches therein apply to this enantiomer only.
(S)-Flurbiprofen is the S-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310+P330-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
