FMoc-nh-peg6-ch2cooh , 95% , 437655-96-4

CAS NO.：437655-96-4

Empirical Formula: C29H39NO10

Molecular Weight: 561.62

MDL number: MFCD26142983

PRODUCT Properties

• storage temp.: 2-8°C
• form: Viscous Liquid
• color: Colorless to light yellow

Description and Uses

Fmoc-NH-PEG6-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].