8-isoProstaglandinF2α , ≥99% , 27415-26-5

CAS NO.：27415-26-5

Empirical Formula: C20H34O5

Molecular Weight: 354.48

MDL number: MFCD00084822

PRODUCT Properties

• Boiling point: 531.0±50.0 °C(Predicted)
• Density: 1.153±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml
• form: A crystalline solid
• pka: 4.76±0.10(Predicted)
• color: White to off-white

Description and Uses

8-iso PGF_2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF_2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF_2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF_2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF_2α inhibits platelet aggregation induced by U-46619 (10⁻⁶ M) and I-BOP (3 x 10⁻⁷ M) with IC₅₀ values of 1.6 x 10⁻⁶ M and 1.8 x 10⁻⁶ M, respectively.

(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360
• Precautionary statements: P201-P202-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501