Metformin-d6(hydrochloride) , ≥98% , 1185166-01-1

Synonym(s):
[²H₆]-Metformin hydrochloride;1,1-Di(methyl-d₃)biguanide hydrochloride

CAS NO.：1185166-01-1

Empirical Formula: C4H6ClD6N5

Molecular Weight: 171.662

MDL number: MFCD06658649

EINECS: 604-604-1

PRODUCT Properties

• Melting point: 215-218°C
• storage temp.: -20°C Freezer
• solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White

Description and Uses

Metformin-d₆ is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53^-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53^-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.

An oral hypoglycemic agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/38
• Safety Statements: 26
• WGK Germany: 3