16-phenoxytetranorProstaglandinF2αmethylester , ≥98% , 51638-90-5

CAS NO.：51638-90-5

Empirical Formula: C23H32O6

Molecular Weight: 404.5

MDL number:

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): .5 mg/ml

Description and Uses

Prostaglandin F_2α (PGF_2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF_2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F_2α (16-phenoxy tetranor PGF_2α) is a metabolically stable form of PGF_2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF_2α. 16-phenoxy tetranor PGF_2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF_2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid[1].

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H319-H360
• Precautionary statements: P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501