Dicyclomine hydrochloride , 98% , 67-92-5
Synonym(s):
[1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride;2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride
CAS NO.：67-92-5
Empirical Formula: C19H36ClNO2
Molecular Weight: 345.95
MDL number: MFCD00079158
EINECS: 200-671-1
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB230.40 | In Stock |
|
| 200mg | RMB390.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 164-166°C |
| storage temp. | -20°C Freezer |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | off-white |
| Water Solubility | H2O: 50mg/mL |
| BCS Class | 2/4 |
| EPA Substance Registry System | 2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride (67-92-5) |
Description and Uses
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; ) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively. Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.
Dicyclomine Hydrochloride can be used as medication to treat gastric diseases.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DT7350000 |
| HS Code | 2922199695 |
| Toxicity | LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82 |
