IvermectinB1a , 98% , 71827-03-7
CAS NO.：71827-03-7
Empirical Formula: C48H74O14
Molecular Weight: 875.09
MDL number:
EINECS: 276-046-2
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB430.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 155-157° |
| Boiling point: | 717.97°C (rough estimate) |
| Density | 1.0683 (rough estimate) |
| refractive index | 1.6130 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 12.42±0.70(Predicted) |
| color | white |
Description and Uses
Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.
Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
