PRODUCT Properties
| Melting point: | 135-136 °C |
| Boiling point: | 106-108 °C(Press: 5 Torr) |
| Density | 1.090 (estimate) |
| refractive index | 1.5605 (estimate) |
| solubility | Soluble in Water, DMSO, DMF, Methanol |
| form | Liquid |
| pka | 8.97±0.10(Predicted) |
| color | Light yellow to brown |
Description and Uses
Aminoethyl-SS-ethylamine contains two primary amine terminal groups and a cleavable disulfide bond. The terminal amines can participate in chemical reactions with carboxylic acids, activated NHS esters and other carbonyl compounds. The disulfide bond can be cleaved by Dithiothreitol (DTT) reagent.
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3].
