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M7364258

Lipoamido-PEG4-acid , 97% , 1314378-10-3

CAS NO.:1314378-10-3

Empirical Formula: C19H35NO7S2

Molecular Weight: 453.61

MDL number: MFCD21363242

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100mg RMB1440.00 In Stock
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Update time: 2022-07-08

Description and Uses

Lipoamido-PEG4-acid contains a lipoic acid group and a terminal carboxylic acid. Lipoic acid contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of the compound.

Lipoamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

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