M7365658
Aurorakinaseinhibitor-2 , ≥99% , 331770-21-9
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2800.00 | In Stock |
|
| 10mg | RMB4640.00 | In Stock |
|
| 25mg | RMB8800.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 518.6±50.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMF:0.25(Max Conc. mg/mL);0.62(Max Conc. mM) DMF:PBS(pH7.2) (1:2):0.33(Max Conc. mg/mL);0.82(Max Conc. mM) DMSO:2.5(Max Conc. mg/mL);6.2(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.01±0.70(Predicted) |
| color | White to yellow |
Description and Uses
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 μM). In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 μM.
Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].