M7458458
Palbociclib-propargyl , 98% , 2366269-23-8
CAS NO.：2366269-23-8
Empirical Formula: C27H31N7O2
Molecular Weight: 485.58
MDL number: MFCD32263448
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB7040.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 711.2±70.0 °C(Predicted) |
| Density | 1.299±0.06 g/cm3(Predicted) |
| form | Solid |
| pka | 5.68±0.10(Predicted) |
| color | Light yellow to yellow |
Description and Uses
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.