ProstaglandinD2serinolamide(PGD2-SA) , 98% , 851761-42-7

CAS NO.：851761-42-7

Empirical Formula: C23H39NO6

Molecular Weight: 425.56

MDL number: MFCD08062228

PRODUCT Properties

• Boiling point: 686.2±55.0 °C(Predicted)
• Density: 1.172±0.06 g/cm3(Predicted)
• solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 5 mg/ml
• pka: 13.86±0.60(Predicted)

Description and Uses

2-Arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB₁ receptor,¹ is an important endogenous monoglyceride species,² and is thus considered to be the natural ligand for the CB₁ receptor. 2-AG can also be sequentially metabolized by COX-2 and specific PG synthases to form PG 2-glyceryl esters.³ In activated RAW 264.7 cells, PGD₂ 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway.³ PGD₂ serinol amide (PGD₂-SA) is a stable analog of PGD₂ 2-glyceryl ester. Unlike PGD₂ 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD₂-SA will not isomerize to the less active primary (1-glyceryl) ester. The biological activity of PGD₂-SA has not yet been determined.

Prostaglandin D2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol[1].

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H319-H360
• Precautionary statements: P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501