8-iso-13,14-dihydro-15-ketoProstaglandinF2α(8-iso-13,14-dihydro-15-ketoPGF2α) , 98% , 191919-02-5

CAS NO.：191919-02-5

Empirical Formula: C20H34O5

Molecular Weight:

MDL number:

PRODUCT Properties

• Boiling point: 543.0±40.0 °C(Predicted)
• Density: 1.091±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: 10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): >10 mg/ml
• pka: 4.76±0.10(Predicted)

Description and Uses

8-iso-13,14-dihydro-15-keto Prostaglandin F_2α (8-iso-13,14-dihydro-15-keto PGF_2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF_2α), in rabbits, monkeys and humans.¹ 8-iso PGF_2α is a PG-like product of non-specific lipid peroxidation.² In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.¹ A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.³ Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF_2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF_2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.⁴

8-iso-13,14-dihydro-15-keto Prostaglandin F2α is an oxidative metabolite of 8-iso-prostaglandin F2α (HY-113209). 8-iso-13,14-dihydro-15-keto Prostaglandin F2α can be used in the study of oxidative stress-related diseases[1].

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger