S1878049
102052-95-9
Synonym(s):
;InSolution EZH2 Inhibitor, DZNep - CAS 102052-95-9 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB1483.68 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 624.1±65.0 °C(Predicted) |
| Density | 1.75 |
| storage temp. | = -70C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| form | Liquid |
| pka | 13.52±0.70(Predicted) |
| color | Beige |
| Water Solubility | Soluble in Water |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1 |
| InChIKey | OMKHWTRUYNAGFG-IEBDPFPHSA-N |
| SMILES | [C@H]1(O)[C@H](N2C3C=CN=C(N)C=3N=C2)C=C(CO)[C@H]1O |
Description and Uses
DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1?Inhibits trimethylation of H3K27 and H4K20?in vitro.1?Selectively induces apoptosis in multiple cancer cell lines with no effect on normal cells.2?DZNep may be used in cocktails to chemically induce pluripotent stem cells (CiPSCs) from somatic cells.3?Enhances angiogenesis in a mouse model of limb ischemia.4
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H335-H315-H319-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
