Sulfamerazine sodium salt , 127-58-2

Synonym(s):
4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide

CAS NO.：127-58-2

Empirical Formula: C11H13N4NaO2S

Molecular Weight: 288.3

MDL number: MFCD00068332

EINECS: 204-851-0

PRODUCT Properties

• RTECS: WP0760000
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO
• form: Powder
• Water Solubility: Soluble in DMSO or water
• CAS DataBase Reference: 127-58-2(CAS DataBase Reference)
• EPA Substance Registry System: Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, monosodium salt (127-58-2)

Description and Uses

Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.

Involved in characterization of chirosan membranes for the transport of drugs1,2,3

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H332-H315-H319
• Precautionary statements: P261-P264-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 20/22-36/38-36/37/38
• Safety Statements: 7-24-45-36-26
• WGK Germany: 3
• TSCA: Yes