≥98%(HPLC) , 300801-52-9

CAS NO.：300801-52-9

Empirical Formula: C13H15NO2S

Molecular Weight: 249.33

MDL number: MFCD00624584

PRODUCT Properties

• Melting point: 132-132.5 °C
• Boiling point: 386.0±42.0 °C(Predicted)
• Density: 1.237±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 33 mg/mL
• form: solid
• pka: -1.76±0.20(Predicted)
• color: pale yellow
• Sensitive: Light Sensitive

Description and Uses

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC₅₀ values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC₅₀ = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3