7-EpiClindamycinHydrochloride

Synonym(s):
Clindamycin 2-dihydrogen phosphate;Clindamycin 2-phosphate

CAS NO.：

Empirical Formula: C18H34ClN2O8PS

Molecular Weight: 504.96

MDL number: MFCD11982855

EINECS: 246-433-0

PRODUCT Properties

• Melting point: 114 °C
• Boiling point: 159°C
• Density: 1.41±0.1 g/cm3(Predicted)
• refractive index: 122 ° (C=1, H2O)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: soluble224mg/mL at 25°C
• form: solid
• pka: pKa 0.964±0.06 (H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
• color: White
• Water Solubility: Freely soluble in water
• Merck: 14,2356
• Stability: Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
• InChIKey: UFUVLHLTWXBHGZ-YFBDLMQENA-N
• SMILES: [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1)O)([C@@H](Cl)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O |&1:0,2,4,5,7,13,18,23,26,r|

Description and Uses

Clindamycin 2-phosphate is a a salt of clincamycin, a semi-synthetic lincosamide. The salt is prepared by selective phosphorylation of the 2-hydroxy moiety of the sugar of clindamycin. The introduction of the phosphate affords improved solubility for injectable formulations. Like other members of the lincosamide family, clindamycin 2-phosphate is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317-H319-H362
• Precautionary statements: P260-P263-P280-P301+P312-P302+P352-P308+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 36-26
• WGK Germany: 3
• RTECS: GF2625000
• HS Code: 29419000