ALuminon , AR , 569-58-4

Synonym(s):
ATA;Aluminon;Aurintricarboxylic acid ammonium salt;Aurin tricarboxylic acid ammonium salt;Aluminon, Ammonium aurin tricarboxylate

CAS NO.：569-58-4

Empirical Formula: C22H17NO9

Molecular Weight: 439.38

MDL number: MFCD00040925

EINECS: 209-319-1

PRODUCT Properties

• Melting point: 220-225 °C (dec.)(lit.)
• Boiling point: 573.92°C (rough estimate)
• Density: 1.4414 (rough estimate)
• bulk density: 400kg/m3
• refractive index: 1.6300 (estimate)
• storage temp.: room temp
• solubility: DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 100 μg/ml
• Colour Index: 43810
• form: powder
• color: Deep red
• PH: 5.3 (10g/l, H2O, 20°C)
• biological source: synthetic
• Water Solubility: 800 g/L (20 ºC)
• λmax: 552 nm (λmax: )
• Merck: 14,322
• BRN: 3900820
• Stability: Stable.
• CAS DataBase Reference: 569-58-4
• EPA Substance Registry System: Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy-, triammonium salt (569-58-4)

Description and Uses

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P280a-P305+P351+P338-P321-P332+P313-P337+P313-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/38-36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 2
• RTECS: GU4800000
• TSCA: Yes
• HS Code: 29189090
• Toxicity: LD50 orally in Rabbit: 9000 mg/kg