Diphenylcyclopropenone , 98% , 886-38-4
Synonym(s):
2,3-Diphenyl-2-cyclopropen-1-one;DPC
CAS NO.：886-38-4
Empirical Formula: C15H10O
Molecular Weight: 206.24
MDL number: MFCD00001311
EINECS: 212-948-4
| Pack Size | Price | Stock | Quantity |
| 1G | RMB126.40 | In Stock |
|
| 5G | RMB614.40 | In Stock |
|
| 25G | RMB2381.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 118-122 °C (lit.) |
| Boiling point: | 305.09°C (rough estimate) |
| Density | 1.232 |
| refractive index | 1.6324 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM) Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM) |
| form | Crystalline Powder |
| color | Slightly pinkish-orange to beige |
| Merck | 14,3308 |
| BRN | 608049 |
| InChI | InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H |
| InChIKey | HCIBTBXNLVOFER-UHFFFAOYSA-N |
| SMILES | C1(=O)C(C2=CC=CC=C2)=C1C1=CC=CC=C1 |
| LogP | 1.769 (est) |
| CAS DataBase Reference | 886-38-4(CAS DataBase Reference) |
Description and Uses
Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.
Diphenylcyclopropenone was used in topical immunotherapy.
