1-Adamantanemethanol , 99% , 770-71-8

Synonym(s):
1-(Hydroxymethyl)adamantane

CAS NO.：770-71-8

Empirical Formula: C11H18O

Molecular Weight: 166.26

MDL number: MFCD00074751

EINECS: 212-225-3

PRODUCT Properties

• Melting point: 114-117 °C (lit.)
• Boiling point: 234.5°C (rough estimate)
• Density: 0.8802 (rough estimate)
• refractive index: 1.5000 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• pka: 15.51±0.10(Predicted)
• form: Crystalline Powder
• color: White
• Water Solubility: Insoluble in water. Solubility in methanol (almost transparency).
• BRN: 1853339
• InChI: InChI=1S/C11H18O/c12-7-11-4-8-1-9(5-11)3-10(2-8)6-11/h8-10,12H,1-7H2
• InChIKey: MDVGOOIANLZFCP-UHFFFAOYSA-N
• SMILES: C12(CO)CC3CC(CC(C3)C1)C2
• CAS DataBase Reference: 770-71-8(CAS DataBase Reference)

Description and Uses

1-Adamantanemethanol acts as guest molecule and forms β-cyclodextrin complexes. It reacts with 3,4,5,6-tetrafluorophthalonitrile to yield 3,4,5,6-tetra-(1-adamantylmethoxy)phthalonitrile.

1-Adamantanemethanol was used in the synthesis of axially disubstituted silicon(IV) phthalocyanines. It is used as a reagent in the synthesis of adamantane and noradamantane based histone deacetylase (HDAC) inhibitors for the treatment of cancer. It is also used as a reagent in the synthesis of (1-adamantyl)methyl glycidyl ether, a versatile building block for living polymerization.
References
Gopalan, B., et al.: Bioorg. Med. Chem. Lett., 23, 2532 (2013);
Suzuki, T., et al.: J. Med. Chem., 55, 9562 (2012);
Moers, C., et al.: Macromol. Rapid Comm., 35, 1075 (2014)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29061900