Amentoflavone , ≥99.0%(HPLC) , 1617-53-4
Synonym(s):
Didemethyl-ginkgetin;I3′,II8-Biapigenin;Tridemethylsciadopitysin
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB207.20 | In Stock |
|
| 25MG | RMB775.20 | In Stock |
|
| 100MG | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >300°C (dec.) |
| Boiling point: | 910.5±65.0 °C(Predicted) |
| Density | 1.656±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
| pka | 6.01±0.40(Predicted) |
| form | Solid |
| color | Yellow |
| BRN | 380244 |
| Major Application | metabolomics vitamins, nutraceuticals, and natural products |
| Cosmetics Ingredients Functions | BLEACHING ANTIOXIDANT |
| InChI | 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| InChIKey | YUSWMAULDXZHPY-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C=C2)OC2=C(C3=CC(C4OC5=CC(O)=CC(O)=C5C(=O)C=4)=CC=C3O)C(O)=CC(O)=C2C(=O)C=1 |
| LogP | 3.492 (est) |
| CAS DataBase Reference | 1617-53-4(CAS DataBase Reference) |
Description and Uses
Amentoflavone is a biflavonoid originally isolated from Selaginella. It has a wide variety of biological effects including antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities. Amentoflavone has antiviral activity against the influenza A subtypes H1N1 and H3N2, influenza B, and herpes simplex virus 1 (EC50s = 3.1 and 4.3, 0.56, and 17.9 μg/ml, respectively). It has antidiabetic effects such that it dose-dependently increases insulin receptor phosphorylation and activation and inhibits hydrolysis of p-nitrophenyl phosphate (p-NPP) catalyzed by protein tyrosine phosphatase 1B (PTP1B; IC50 = 7.3 μM). Amentoflavone reduces the time mice spend immobile in the forced swim test, a measure of antidepressant efficacy, in a dose-dependent manner.
Amentoflavone, is isolated from an Et acetate ext. of the whole plant of Selaginella tamariscina. It has been shown to have antitumor activity, such as mitochondria-mediated apoptotic cell death. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body.
