Barasertib (AZD1152-HQPA) , ≥97% , 722544-51-6

Synonym(s):
3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide

CAS NO.：722544-51-6

Empirical Formula: C26H30FN7O3

Molecular Weight: 507.56

MDL number: MFCD10687152

Pack Size	Price	Stock	Quantity
10MG	RMB586.40	In Stock
50MG	RMB2399.20	In Stock
250MG	RMB7199.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Boiling point:	796.7±60.0 °C(Predicted)
Density	1.359±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >15mg/mL
pka	13.07±0.10(Predicted)
form	powder
color	white to beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey	QYZOGCMHVIGURT-UHFFFAOYSA-N
SMILES	N1C(NC2=C3C(=NC=N2)C=C(OCCCN(CC)CCO)C=C3)=CC(CC(NC2=CC=CC(F)=C2)=O)=N1
CAS DataBase Reference	722544-51-6

Description and Uses

AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1?Aurora B Ki?= 0.36 nM; Aurora A Ki?= 1,369 nM.2?It inhibits the growth of tumors in multiple cancer models.3-6?Excessive ROS generation7?and upregulated tumor suppressor miRNAs8?have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.

AZD1152-HQPA has been used:

for the dose dependent inhibition of aurora kinase B (AURKB)
as a component to identify that, replication timing regulatory factor 1 (RIF1) and protein phosphatase 1 (PP1) are critical for the regulation of abscission timing in human cells
as a component to study the relevance of AURKB as a cancer therapeutic target