Barasertib (AZD1152-HQPA) , ≥97% , 722544-51-6

Synonym(s):
3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide

CAS NO.：722544-51-6

Empirical Formula: C26H30FN7O3

Molecular Weight: 507.56

MDL number: MFCD10687152

PRODUCT Properties

• Boiling point: 796.7±60.0 °C(Predicted)
• Density: 1.359±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: >15mg/mL
• pka: 13.07±0.10(Predicted)
• form: powder
• color: white to beige
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChIKey: QYZOGCMHVIGURT-UHFFFAOYSA-N
• SMILES: N1C(NC2=C3C(=NC=N2)C=C(OCCCN(CC)CCO)C=C3)=CC(CC(NC2=CC=CC(F)=C2)=O)=N1
• CAS DataBase Reference: 722544-51-6

Description and Uses

AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1Aurora B Ki= 0.36 nM; Aurora A Ki= 1,369 nM.2It inhibits the growth of tumors in multiple cancer models.3-6Excessive ROS generation7and upregulated tumor suppressor miRNAs8have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.

AZD1152-HQPA is a a highly selective inhibitor of aurora-B kinase. AZD1152-HQPA has been shown to inhibit osteosarcoma cell line U2-OS cells proliferation. AZD1152-HQPA was also shown to be an effective apoptosis-inducing agent in acute myeloid leukemia cell lines and primary acute myeloid leukemia cultures.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids