Avasimibe , ≥98% , 166518-60-1

Synonym(s):
CI-1011; PD 148515; [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid

CAS NO.：166518-60-1

Empirical Formula: C29H43NO4S

Molecular Weight: 501.72

MDL number: MFCD00934956

EINECS: 1592732-453-0

Pack Size	Price	Stock	Quantity
10MG	RMB399.20	In Stock
50MG	RMB1439.20	In Stock
250MG	RMB4799.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	178-180° (Lee); mp 169.5-170.4° (Dozeman)
Density	1.072±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: ≥40mg/mL
form	powder
pka	1.97±0.70(Predicted)
color	white to tan
InChI	1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)
InChIKey	PTQXTEKSNBVPQJ-UHFFFAOYSA-N
SMILES	CC(C)c1cc(C(C)C)c(CC(=O)NS(=O)(=O)Oc2c(cccc2C(C)C)C(C)C)c(c1)C(C)C

Description and Uses

Avasimibe has been used as an inhibitor of acyl-coenzyme A: cholesterol acyltransferase (ACAT) in Huh7.5.1 cells for testing its combination with direct-acting antivirals (DAAs) and to test its effect on lipid droplet accumulation in acidosis-adapted cancer cells. It may be used as an inhibitor of ACAT to assess cholesterol esterification in Trypanosoma cruzi.