Bromocriptinemesylate , 99% , 22260-51-1
Synonym(s):
(+)-2-Bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)ergotaman-3′,6′-18-trione methanesulfonate salt;(+)-Bromocriptine methanesulfonate salt;2-Bromo-α-ergocryptine methanesulfonate salt;Bromocriptine mesylate salt
CAS NO.：22260-51-1
Empirical Formula: C33H44BrN5O8S
Molecular Weight: 750.7
MDL number: MFCD00069218
EINECS: 244-881-1
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB399.20 | In Stock |
|
| 250mg | RMB1119.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 192-196° (dec) |
| alpha | D20 +95° (c = 1 in methanol-methylene chloride) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.8 mg/mL |
| form | solid |
| pka | 4.90(at 25℃) |
| color | white |
| optical activity | [α]20/D +95°, c = 1 in methanol: methylene chloride (1:1)(lit.) |
| Water Solubility | H2O: 0.8mg/mL ethanol: 23mg/mL |
| Merck | 13,1400 |
| BRN | 4115238 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChIKey | NOJMTMIRQRDZMT-JGYCFGIMSA-N |
| SMILES | N12[C@@H](CC(C)C)C(N3CCC[C@@]3([H])[C@]1(O)O[C@@](C(C)C)(NC(=O)[C@H]1CN(C3CC4=C(NC5C=CC=C(C4=5)C3=C1)Br)C)C2=O)=O.S(=O)(=O)(O)C |&1:1,11,13,16,23,r| |
| CAS DataBase Reference | 22260-51-1(CAS DataBase Reference) |
Description and Uses
Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5 receptors, respectively). It also binds to the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as α1-adrenergic receptors (Kis = 1.12-4.17 nM). Bromocriptine (5 mg/kg) restores locomotor activity, without inducing dyskinesia, in a macaque model of Parkinson’s disease induced by MPTP. Formulations containing bromocriptine have been used in the treatment of Parkinson''s disease, hyperprolactinemia-associated dysfunctions, and acromegaly.
Dopamine receptor agonist; derivative of the ergotoxin group of ergot alkaloids. Prolactin inhibitor; antiparkinsonian.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P273-P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 22-24/25-36 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | KE1595000 |
| F | 3-10 |
| HS Code | 29396900 |
| Toxicity | LD50 in mice, rats, rabbits (mg/kg): 190, 72, 12.5 i.v. (Parkes) |
