NS6180 , 98% , 353262-04-1

Synonym(s):
4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

CAS NO.：353262-04-1

Empirical Formula: C16H12F3NOS

Molecular Weight: 323.33

MDL number:

PRODUCT Properties

• Boiling point: 476.9±45.0 °C(Predicted)
• Density: 1.375±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: soluble20mg/mL, clear
• pka: 0.53±0.20(Predicted)
• form: powder
• color: white to beige
• InChI: 1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2
• InChIKey: ZUIJXKLTUFCDGO-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1cc(ccc1)CN2c3c(cccc3)SCC2=O

Description and Uses

NS 6180 increases the proliferation of both A-NK and NA-NK cells. NS 6180 is a new KCa3.1 channel inhibitor that prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H317-H411
• Precautionary statements: P273-P280-P302+P352
• Hazard Codes: Xi,N
• Risk Statements: 43-51/53
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 2; Skin Sens. 1