Benserazide hydrochloride , 98% , 14919-77-8

Synonym(s):
DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

CAS NO.：14919-77-8

Empirical Formula: C10H16ClN3O5

Molecular Weight: 293.7

MDL number: MFCD00078571

EINECS: 238-991-9

PRODUCT Properties

• Melting point: 146°C
• storage temp.: 2-8°C
• solubility: H₂O: 10 mg/mL
• form: solid
• color: White to Off-White
• PH: pH(10g/L, 25℃) : 4.0～5.0
• biological source: synthetic
• Water Solubility: Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
• λmax: 272nm(HCl aq.)(lit.)
• Sensitive: Light Sensitive
• Merck: 14,1050
• InChI: InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
• InChIKey: ULFCBIUXQQYDEI-UHFFFAOYSA-N
• SMILES: C(NNCC1=CC=C(O)C(O)=C1O)(=O)C(CO)N.[H]Cl
• CAS DataBase Reference: 14919-77-8(CAS DataBase Reference)

Description and Uses

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

Antiparkinsonian;DOPA decarboxylase inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: VT9632300
• HS Code: 29280000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3