Brefeldin A , fromPenicilliumbrefeldianum,≥98%(HPLC) , 20350-15-6

Synonym(s):
BFA;1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one;Ascotoxin;γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone;Cyanein

CAS NO.：20350-15-6

Empirical Formula: C16H24O4

Molecular Weight: 280.36

MDL number: MFCD00083258

EINECS: 606-528-3

PRODUCT Properties

• Melting point: 200-205 °C
• Boiling point: 492.7±45.0 °C(Predicted)
• alpha: 93 º (C=2 IN MEOH)
• Density: 1.108±0.06 g/cm3(Predicted)
• vapor pressure: 0.56 hPa ( 20 °C)
• Flash point: 87 °C
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: methanol: 10 mg/mL, clear, colorless to faintly yellow
• pka: 12.92±0.60(Predicted)
• form: Crystalline Powder
• color: White to almost white
• biological source: Penicillium brefeldianum
• Water Solubility: Soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water.
• Merck: 13,1355
• BRN: 25191
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• InChIKey: QSECOIOBNZLGOD-OBCVZTHZSA-N
• CAS DataBase Reference: 20350-15-6

Description and Uses

Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable.

Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumour and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P310
• Hazard Codes: Xn,T
• Risk Statements: 22-25-36/37/38-20/21/22
• Safety Statements: 24/25-45-36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: GY8410000
• Autoignition Temperature: 301 °C
• HS Code: 29411090
• Toxicity: LD50 i.p. in mice: >200 mg/kg (Haerri)