Benzyl carbazate , 98% , 5331-43-1

Synonym(s):
(Benzyloxycarbonyl)hydrazine;Z-hydrazine

CAS NO.：5331-43-1

Empirical Formula: C8H10N2O2

Molecular Weight: 166.18

MDL number: MFCD00041890

EINECS: 226-230-3

PRODUCT Properties

• Melting point: 65-68 °C (lit.)
• Boiling point: 294.38°C (rough estimate)
• Density: 1.2265 (rough estimate)
• refractive index: 1.6180 (estimate)
• Flash point: >230 °F
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO, Methanol
• form: Solid
• pka: 10.56±0.20(Predicted)
• color: Beige
• Water Solubility: Soluble in water (slightly), methanol and DMSO.
• BRN: 1952982
• Major Application: peptide synthesis
• InChI: 1S/C8H10N2O2/c9-10-8(11)12-6-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11)
• InChIKey: RXUBZLMIGSAPEJ-UHFFFAOYSA-N
• SMILES: NNC(=O)OCc1ccccc1
• CAS DataBase Reference: 5331-43-1(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, phenylmethyl ester(5331-43-1)
• EPA Substance Registry System: Hydrazinecarboxylic acid, phenylmethyl ester (5331-43-1)

Description and Uses

Benzyl carbazate is used as a reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method. It is also used in the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H318
• Precautionary statements: P280-P305+P351+P338
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 41
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: MV1724950
• TSCA: TSCA listed
• HS Code: 29280000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Dam. 1